Istradefylline 40 mg/working day elevated peak levels and AUC of CYP3A4 substrates in scientific trials. This result wasn't observed with istradefylline 20 mg/working day. Think about dose reduction of delicate CYP3A4 substrates.Due to the fact CYP3A4 inhibition elevates ergotamine and caffeine serum degrees, the danger for vasospasm resulting in c